Evaluation of oxidative stress in D-serine induced nephrotoxicity
M Orozco-Ibarra, ON Medina-Campos… - Toxicology, 2007 - Elsevier
It has been suggested that oxidative stress is involved in d-serine-induced nephrotoxicity.
The purpose of this study was to assess if oxidative stress is involved in this experimental
model using several approaches including (a) the determination of several markers of
oxidative stress and the activity of some antioxidant enzymes in kidney and (b) the use of
compounds with antioxidant or prooxidant effects. Rats were sacrificed at several periods of
time (from 3 to 24h) after a single ip injection of d-serine (400mg/kg). Control rats were …
The purpose of this study was to assess if oxidative stress is involved in this experimental
model using several approaches including (a) the determination of several markers of
oxidative stress and the activity of some antioxidant enzymes in kidney and (b) the use of
compounds with antioxidant or prooxidant effects. Rats were sacrificed at several periods of
time (from 3 to 24h) after a single ip injection of d-serine (400mg/kg). Control rats were …
